Rabbit Polyclonal SOX1 Antibody

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human liver cancer tissue, 293T cells, Primary antibody: P04207(SOX1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

SOX1 antibodies are autoantibodies targeting SOX1. a member of the SOX (SRY-related HMG-box) family of transcription factors. SOX1 plays a critical role in early neurogenesis, particularly in the development and maintenance of neural progenitor cells within the central nervous system. It regulates the differentiation of neurons and glial cells, with expression predominantly observed in the embryonic neural tube and adult neural tissues.

Clinically, SOX1 antibodies are recognized as biomarkers for paraneoplastic neurological syndromes (PNS), especially in association with small cell lung cancer (SCLC). Their presence is strongly linked to Lambert-Eaton myasthenic syndrome (LEMS) and paraneoplastic cerebellar degeneration (PCD). Detection of SOX1 antibodies aids in distinguishing paraneoplastic from non-paraneoplastic neurological disorders, enhancing diagnostic accuracy. While not exclusive to malignancy, their high specificity for SCLC (reported in ~60-70% of LEMS cases) underscores their utility in prompting oncological evaluation.

Testing typically involves indirect immunofluorescence or immunoblot assays using recombinant SOX1 proteins. However, interpretation requires correlation with clinical context, as SOX1 antibodies may coexist with other onconeural antibodies (e.g., anti-Hu, anti-Yo). Research continues to explore their pathogenic role, though current evidence suggests they may serve as epiphenomena rather than direct contributors to neurological damage. Their identification remains a key component in the diagnostic workup of autoimmune neurological disorders with suspected paraneoplastic etiology.