Rabbit Polyclonal SLC12A6 Antibody

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11823(HRG Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11823(HRG Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The SLC12A6 antibody is a tool used to detect the solute carrier family 12 member 6 (SLC12A6) protein, also known as potassium-chloride cotransporter 3 (KCC3). This transmembrane protein, encoded by the *SLC12A6* gene, plays a critical role in regulating intracellular chloride and potassium ion homeostasis, particularly in neurons and peripheral nerves. It facilitates electroneutral ion transport, contributing to cell volume regulation and neuronal excitability. Dysfunction of SLC12A6 is linked to neurological disorders, including Andermann syndrome (a rare autosomal recessive condition characterized by agenesis of the corpus callosum, peripheral neuropathy, and developmental delays) and other neuromuscular pathologies.

SLC12A6 antibodies are widely utilized in research to investigate the protein's expression, localization, and functional interactions. They are applied in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study tissue-specific distribution, particularly in the nervous system. Studies using these antibodies have revealed SLC12A6's involvement in axonal maintenance, synaptic function, and osmoregulation. Additionally, the antibody aids in exploring disease mechanisms, such as how SLC12A6 mutations disrupt ion transport, leading to neurodegeneration. Its role in cancer cell migration and epilepsy has also been investigated, highlighting its broader physiological relevance. Validated antibodies are essential for distinguishing between SLC12A6 isoforms and assessing post-translational modifications, contributing to targeted therapeutic research.