Rabbit Polyclonal SLC4A7 Antibody

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P04195(SLC4A7 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P04195(SLC4A7 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The solute carrier family 4 member 7 (SLC4A7), also known as NBCn1. is a sodium bicarbonate cotransporter involved in pH homeostasis and ion transport across cell membranes. It plays critical roles in regulating intracellular pH, cell migration, and electrolyte balance, particularly in tissues such as the kidney, brain, and heart. Dysregulation of SLC4A7 has been implicated in various pathologies, including cancer metastasis, hypertension, and neurological disorders. For instance, SLC4A7 overexpression in breast and pancreatic cancers is linked to enhanced tumor progression via pH-dependent mechanisms that promote cell survival and invasion.

SLC4A7 antibodies are essential tools for studying the protein's expression, localization, and function. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect SLC4A7 in tissue samples or cell lines. Researchers rely on them to investigate SLC4A7's role in cellular processes, such as acid-base transport and its interaction with signaling pathways like PI3K/AKT. Validated antibodies help identify SLC4A7 as a potential biomarker or therapeutic target in diseases. Specificity and cross-reactivity across species (e.g., human, mouse) are key considerations when selecting SLC4A7 antibodies. Recent studies also explore its involvement in drug resistance, highlighting its clinical relevance. Proper antibody validation ensures accurate data, advancing both basic research and translational applications.