Rabbit Polyclonal HCRTR2 Antibody

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of HL-60 cells using CD230 mouse mAb (green) and negative control (red).    

  
  

The hypocretin receptor 2 (HCRTR2), also known as orexin receptor type 2. is a G protein-coupled receptor primarily expressed in the central nervous system. It binds hypocretin (orexin) neuropeptides, which regulate arousal, sleep-wake cycles, appetite, and energy homeostasis. HCRTR2 dysfunction is linked to narcolepsy type 1 (characterized by hypocretin deficiency) and neurological disorders like epilepsy.

HCRTR2 antibodies are essential tools for studying receptor localization, expression, and function in research. These antibodies, often developed in rabbits or mice, enable techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize HCRTR2 distribution in brain tissues or cultured cells. Specificity is validated via knockout controls or peptide-blocking assays to ensure minimal cross-reactivity with related receptors like HCRTR1.

Research applications include exploring HCRTR2's role in sleep disorders, metabolic regulation, and neurodegenerative diseases. Antibodies also aid in drug development targeting HCRTR2 for insomnia or obesity. However, challenges like tissue-specific isoform detection or post-translational modification variability require careful antibody validation. Overall, HCRTR2 antibodies remain pivotal in unraveling the receptor's pathophysiology and therapeutic potential.