Rabbit Polyclonal GRIN2C Antibody

The GRIN2C antibody is a research tool used to detect and study the GRIN2C protein, which encodes the GluN2C subunit of the N-methyl-D-aspartate (NMDA) receptor. NMDA receptors are ionotropic glutamate receptors critical for synaptic plasticity, learning, and memory. The GluN2C subunit, one of four GluN2 variants (GluN2A-D), combines with the obligatory GluN1 subunit to form functional receptor complexes. GRIN2C is predominantly expressed in the thalamus, cerebellum, and hippocampus, with distinct regional and developmental expression patterns compared to other GluN2 subunits. Antibodies targeting GRIN2C enable researchers to investigate its expression, localization, and role in neuronal signaling through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of GRIN2C has been implicated in neurological disorders, including epilepsy, schizophrenia, and neurodevelopmental conditions. Studies using GRIN2C antibodies have helped elucidate its contribution to receptor kinetics, synaptic integration, and disease mechanisms. These antibodies are often validated for specificity against recombinant proteins or tissue samples lacking GRIN2C expression. Their application supports both basic neuroscience research and preclinical studies targeting NMDA receptor dysfunction.