Rabbit Polyclonal AKAP8 Antibody

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: HL60 cell lysate, Primary antibody: P07320(CSF2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P07320(CSF2 Antibody) at dilution 1/150. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07320(CSF2 Antibody) at dilution 1/150. (Original magnification: ×200)    

  
  

The A-kinase anchoring protein 8 (AKAP8) is a member of the AKAP family, which compartmentalizes protein kinase A (PKA) and other signaling molecules to regulate localized cellular processes. AKAP8. also known as AKAP95. is primarily nuclear and plays roles in transcriptional regulation, RNA processing, and chromatin remodeling by tethering PKA and other partners (e.g., protein phosphatases, RNA-binding proteins) to specific subcellular sites. It is implicated in cell cycle progression, DNA repair, and maintaining genomic stability.

AKAP8 antibodies are essential tools for studying its expression, localization, and interactions in these pathways. They are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore AKAP8's functional dynamics in health and disease. Research links AKAP8 dysregulation to cancers, neurodevelopmental disorders, and cardiovascular diseases, making its antibodies valuable for mechanistic and diagnostic studies.

Structurally, AKAP8 contains conserved domains for PKA binding and nucleic acid interactions. Alternative splicing generates isoforms (e.g., AKAP8 and AKAP8B), and some antibodies distinguish these variants by targeting unique epitopes. Validation of AKAP8 antibodies ensures specificity, as cross-reactivity with homologous proteins (e.g., AKAP8L) can occur. Ongoing research aims to clarify its tissue-specific roles and therapeutic potential, underscoring the importance of reliable AKAP8 antibodies in biomedical research.