Rabbit Polyclonal MMP24 Antibody

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P04117(MMP24 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

MMP24 (Matrix Metalloproteinase 24), also known as MT5-MMP, is a member of the zinc-dependent endopeptidase family involved in extracellular matrix (ECM) remodeling. It is characterized by a conserved domain structure, including a propeptide, catalytic, hinge, and hemopexin-like domain. Unlike many MMPs, MMP24 is membrane-anchored via a transmembrane domain or glycosylphosphatidylinositol (GPI) linkage, enabling localized proteolytic activity. It plays roles in neural development, tissue repair, and pathological processes such as cancer progression and neurodegeneration. MMP24 is expressed in the brain, kidneys, and reproductive tissues, with elevated levels observed in glioblastoma, Alzheimer’s disease, and osteoarthritis.

MMP24 antibodies are essential tools for studying its expression, localization, and function. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect MMP24 in biological samples. Some antibodies target specific domains (e.g., catalytic or hemopexin regions) to investigate structure-function relationships or inhibit enzymatic activity. Research highlights MMP24's involvement in activating pro-MMP2 and degrading ECM components like collagen IV, influencing cell migration and invasion. Dysregulation of MMP24 is linked to tumor metastasis and neuroinflammation, making it a potential therapeutic target. Antibodies against MMP24 aid in elucidating its mechanisms in disease models and validating its role as a biomarker or drug candidate.