Rabbit Polyclonal SLC16A1 Antibody

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P04098(SLC16A1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04098(SLC16A1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P04098(SLC16A1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SLC16A1 antibody targets the solute carrier family 16 member 1 (SLC16A1), a gene encoding monocarboxylate transporter 1 (MCT1). MCT1 is a transmembrane protein responsible for transporting monocarboxylates, such as lactate, pyruvate, and ketone bodies, across cell membranes. This transporter plays a critical role in cellular metabolism by facilitating the exchange of these metabolites, which is particularly vital in tissues with high energy demands, including skeletal muscle, the heart, and the brain. Dysregulation of MCT1 is linked to metabolic disorders, cancer progression, and neurodegenerative diseases, as cancer cells often rely on lactate export to sustain glycolytic activity (Warburg effect).

SLC16A1 antibodies are widely used in research to study MCT1 expression, localization, and function in normal and pathological conditions. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding in the characterization of metabolic adaptations in tumors or metabolic diseases. Many antibodies are validated for specificity against human, mouse, or rat MCT1. with some targeting specific epitopes or post-translational modifications. Recent studies also explore MCT1's role in the tumor microenvironment and its potential as a therapeutic target, driving demand for reliable antibodies. Proper validation, including knockout controls, is essential to ensure accurate interpretation of experimental results.