Rabbit Polyclonal MC5R Antibody

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P04097(MC5R Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

Melanocortin 5 receptor (MC5R) antibody is a research tool designed to detect and study the MC5R protein, a member of the melanocortin receptor family. MC5R is a G protein-coupled receptor (GPCR) that binds α-melanocyte-stimulating hormone (α-MSH) and other melanocortin peptides. It is widely expressed in peripheral tissues, including exocrine glands, adipose tissue, and immune cells, and is implicated in diverse physiological processes such as sebum production, thermoregulation, immune modulation, and energy homeostasis. Dysregulation of MC5R signaling has been linked to metabolic disorders, inflammation, and cancer.

MC5R antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant proteins corresponding to specific epitopes of the receptor. These antibodies enable the detection of MC5R in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the localization and quantification of the receptor in tissues or cell lines. Validation often includes knockout controls to confirm specificity.

Research utilizing MC5R antibodies has advanced understanding of its role in lipid metabolism, immune responses, and endocrine regulation. They are critical tools for exploring MC5R's therapeutic potential in conditions like obesity, diabetes, and autoimmune diseases. Challenges remain in ensuring antibody specificity due to homology among melanocortin receptors, underscoring the need for rigorous validation in experimental models.