Rabbit Polyclonal MAFF Antibody

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04088(MAFF Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P04088(MAFF Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

MAFF (Musculoaponeurotic Fibrosarcoma Oncogene Homolog F) is a member of the MAF family of transcription factors, which includes proteins like MAFA, MAFB, and c-MAF. Identified initially for its homology to viral oncogenes, MAFF regulates gene expression by forming homodimers or heterodimers with other bZIP proteins, such as NRF2. to bind antioxidant response elements (ARE) in target gene promoters. It plays a critical role in cellular stress responses, including oxidative and electrophilic stress, by activating cytoprotective pathways. MAFF also contributes to inflammation, differentiation, and tissue homeostasis.

MAFF antibodies are essential tools for studying its expression, localization, and interactions in various biological contexts. Research links MAFF dysregulation to diseases like cancer, where it may act as both oncogene and tumor suppressor depending on context. For example, MAFF overexpression is observed in certain carcinomas (e.g., liver, breast) but is downregulated in others (e.g., colorectal). Its dual role in promoting survival or apoptosis under stress makes it a focus in therapeutic targeting.

These antibodies are widely used in techniques like Western blotting, immunofluorescence, and ChIP-seq to explore MAFF's regulatory networks. Commercially available MAFF antibodies are typically validated for specificity against conserved epitopes, aiding research into its pathological and physiological roles.