Rabbit Polyclonal LAMA1 Antibody

+ +

•  

   

     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

•  

   

     Western blot analysis using ALDOA mouse mAb against MCF-7 (1), Hela (2), and NIH/3T3 (3) cell lysate.    

  
  

•  

   

     Flow cytometric analysis of K562 cells using ALDOA mouse mAb (green) and negative control (red).    

  
  

•  

   

     Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using ALDOA mouse mAb with DAB staining.    

  
  

•  

   

     Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using ALDOA mouse mAb with DAB staining.    

  
  

**Background of LAMA1 Antibody**

The LAMA1 antibody targets laminin subunit alpha-1 (LAMA1), a critical component of laminins—a family of extracellular matrix glycoproteins essential for tissue structure and cellular signaling. LAMA1 is a key subunit of laminin-111 (α1β1γ1), predominantly found in basement membranes during early development. It plays vital roles in cell adhesion, differentiation, and tissue organization by interacting with integrins and other cell surface receptors.

Research on LAMA1 has focused on its involvement in embryonic development, particularly in neural tube formation, muscle integrity, and kidney morphogenesis. Mutations in the *LAMA1* gene are linked to human disorders such as Poretti-Boltshauser syndrome, characterized by brain malformations and retinal defects. In cancer, altered LAMA1 expression is associated with tumor progression and metastasis, reflecting its dual role in both supporting tissue architecture and modulating pathogenic processes.

LAMA1 antibodies are widely used in immunohistochemistry, Western blotting, and immunofluorescence to study protein localization, expression levels, and basement membrane composition in normal and diseased tissues. These tools have advanced understanding of developmental biology, regenerative medicine, and mechanisms underlying genetic or acquired diseases. Commercial LAMA1 antibodies are typically validated for specificity across species, including human, mouse, and rat, ensuring broad applicability in preclinical and clinical research.