Rabbit Polyclonal LEPR Antibody

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P04071(LEPR Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P04071(LEPR Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

**Background of LEPR Antibodies**

The leptin receptor (LEPR), a key player in energy homeostasis, mediates the effects of leptin—a hormone secreted by adipose tissue that regulates appetite, metabolism, and body weight. LEPR belongs to the class I cytokine receptor family and exists in multiple splice variants, with the long isoform (LEPRb) being critical for intracellular signaling via JAK-STAT pathways. Dysregulation of leptin-LEPR signaling is linked to obesity, metabolic disorders, and immune dysfunction.

LEPR antibodies are essential tools for studying receptor expression, localization, and function. They enable detection of LEPR in tissues (e.g., hypothalamus, immune cells) using techniques like immunohistochemistry, Western blotting, or flow cytometry. Specific antibodies can distinguish between LEPR isoforms or phosphorylated forms, aiding research into signaling mechanisms. Additionally, neutralizing LEPR antibodies help explore leptin resistance, a hallmark of obesity, while agonist antibodies may probe therapeutic strategies.

Research applications span obesity, diabetes, and cancer, as leptin influences tumor growth and immune responses. Mutations in *LEPR* cause severe early-onset obesity, underscoring its physiological importance. Commercial LEPR antibodies vary in specificity (monoclonal vs. polyclonal) and cross-reactivity across species, requiring validation for experimental models. Overall, LEPR antibodies remain vital for unraveling metabolic regulation and developing targeted therapies.