Rabbit Polyclonal KCNC2 Antibody

The KCNC2 antibody is a specialized tool used to detect the KCNC2 protein, encoded by the *KCNC2* gene, which belongs to the Shaw subfamily of voltage-gated potassium (Kv) channels. KCNC2. also known as Kv3.2. plays a critical role in regulating neuronal excitability, particularly in fast-spiking neurons. It facilitates high-frequency action potential firing by enabling rapid repolarization of the membrane potential, a feature essential for precise timing in neural circuits. This protein is predominantly expressed in the brain, including regions like the cerebellum, basal ganglia, and auditory brainstem, and is implicated in motor coordination, sensory processing, and cognitive functions. Antibodies targeting KCNC2 are widely used in neuroscience research to study channel distribution, expression levels, and functional roles in both physiological and pathological contexts, such as epilepsy, neurodegenerative diseases, and hearing disorders. These antibodies are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of Kv3.2's contribution to synaptic transmission and network synchronization. Understanding KCNC2's mechanisms through antibody-based assays provides insights into potential therapeutic strategies for neurological conditions linked to potassium channel dysfunction.