Rabbit Polyclonal IQGAP2 Antibody

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using RAF1 mouse mAb against Hela (1), A431 (2), Cos7 (3) and C6 (4) cell lysate.    

  
  

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     Flow cytometric analysis of Hela cells using RAF1 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using RAF1 mouse mAb with DAB staining.    

  
  

The IQGAP2 antibody is a research tool designed to detect and study IQGAP2. a member of the IQ motif-containing GTPase-activating protein (IQGAP) family. IQGAP proteins, including IQGAP1. IQGAP2. and IQGAP3. function as scaffolding molecules regulating cellular processes such as cytoskeletal dynamics, cell adhesion, and signaling. IQGAP2. encoded by the *IQGAP2* gene, interacts with Rho-family GTPases (e.g., Cdc42. Rac1) and other partners to modulate cell polarity, migration, and vesicle trafficking. Unlike IQGAP1. which is linked to cancer progression, IQGAP2 is implicated in metabolic regulation and tumor suppression, particularly in liver and gastrointestinal tissues.

IQGAP2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions. Their specificity is critical, as IQGAP2 shares structural homology with IQGAP1. necessitating validation to avoid cross-reactivity. Studies employing these antibodies have revealed IQGAP2’s role in maintaining tissue integrity, glucose homeostasis, and apoptosis. Dysregulation of IQGAP2 is associated with diseases such as hepatocellular carcinoma, diabetes, and non-alcoholic fatty liver disease (NAFLD), highlighting its potential as a therapeutic or diagnostic target.

Research continues to explore IQGAP2’s molecular mechanisms, with its antibody serving as a key reagent in dissecting pathways involving GTPase signaling, cell-cell junctions, and metabolic regulation.