Rabbit Polyclonal HOXC6 Antibody

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Huvec cell, Primary antibody: P04034(HOXC6 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

**Background of HOXC6 Antibody**

HOXC6 is a member of the HOX gene family, which encodes transcription factors critical for embryonic development, particularly in establishing body patterning and cellular differentiation. Located on chromosome 12q13.13. HOXC6 regulates morphogenesis by controlling gene expression in specific spatial and temporal contexts. It plays roles in limb development, neural tube formation, and organogenesis. In adult tissues, HOXC6 expression persists in certain organs, such as the prostate, uterus, and mammary glands, where it influences cellular proliferation and differentiation.

Antibodies targeting HOXC6 are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect HOXC6 protein levels in cells and tissues. Such antibodies aid in exploring HOXC6's involvement in developmental disorders and diseases, including cancer. For instance, aberrant HOXC6 expression is linked to tumor progression in prostate, breast, and ovarian cancers, where it may promote metastasis or therapy resistance.

HOXC6 antibodies also support research into stem cell biology, as HOXC6 regulates stem cell differentiation and tissue regeneration. Validation of these antibodies includes specificity checks using knockout controls and cross-reactivity assessments. Understanding HOXC6's role through antibody-based studies provides insights into developmental pathways and potential therapeutic targets for cancers or regenerative medicine.