Rabbit Polyclonal HOXC8 Antibody

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04032(HOXC8 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P04032(HOXC8 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The HOXC8 antibody is a crucial tool for studying the HOXC8 protein, a member of the HOX gene family that regulates embryonic development, particularly in segmental patterning and limb morphogenesis. HOX genes encode transcription factors containing a conserved homeodomain, enabling DNA binding to regulate downstream genes. HOXC8. located on chromosome 12. plays roles in skeletal development, cellular differentiation, and tissue homeostasis. Dysregulation of HOXC8 is implicated in cancers (e.g., breast, colorectal) and developmental disorders, making its detection vital for research.

The HOXC8 antibody allows precise localization and quantification of HOXC8 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in exploring HOXC8's involvement in disease mechanisms, such as promoting tumor invasiveness or metastasis. Monoclonal antibodies offer high specificity, while polyclonal versions may detect multiple epitopes. Validation via knockout controls or peptide-blocking assays ensures reliability.

Researchers use HOXC8 antibodies to investigate its role as a potential biomarker for prognosis or therapeutic targeting. In developmental biology, these antibodies help map HOXC8 expression patterns during embryogenesis. Their application bridges basic research and clinical studies, offering insights into HOXC8's dual functions in normal physiology and pathology.