基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 一抗 多抗 GFRA1 antibody GFRA1抗体
  • Rabbit Polyclonal GFRA1 Antibody
  • Rabbit Polyclonal GFRA1 Antibody
  • Rabbit Polyclonal GFRA1 Antibody

1/3

Rabbit Polyclonal GFRA1 Antibody

Rabbit Polyclonal GFRA1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
GFRA1抗体
英文名称：
Rabbit Polyclonal GFRA1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 33 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
GFRA1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GFRA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Rat brain tissue lysate, Primary antibody: P03985(GFRA1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P03985(GFRA1 Antibody) at dilution 1/65. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P03985(GFRA1 Antibody) at dilution 1/65. (Original magnification: ×200)    


           

参考文献

以下是关于GFRA1抗体的参考文献示例(内容为假设性构造，仅用于演示格式)：

---

1. **文献名称**: "GFRA1 Expression in Enteric Nervous System Development"

**作者**: Smith A, et al.

**摘要**: 本研究利用GFRA1特异性抗体，通过免疫组化和Western blot技术，揭示了GFRA1在胚胎期肠神经系统中的动态表达模式。结果表明，GFRA1与RET受体协同调节神经嵴细胞的迁移和分化，为肠道神经发育异常提供了分子机制解释。

2. **文献名称**: "Role of GFRA1 in Parkinson's Disease Models"

**作者**: Chen L, et al.

**摘要**: 通过免疫荧光和流式细胞术结合GFRA1抗体，研究发现在帕金森病小鼠模型中，中脑多巴胺能神经元的GFRA1表达显著下调。进一步实验表明，外源性GDNF通过GFRA1/RET通路促进神经元存活，提示其潜在治疗价值。

3. **文献名称**: "GFRA1 as a Biomarker in Neuroblastoma"

**作者**: Tanaka K, et al.

**摘要**: 使用GFRA1抗体对儿童神经母细胞瘤组织进行染色，发现高表达GFRA1的肿瘤具有更强的侵袭性和耐药性。体外实验证实，GFRA1沉默可抑制肿瘤细胞增殖，支持其作为预后标志物和治疗靶点的潜力。

---

*注：以上文献为示例，实际研究中请通过PubMed或Web of Science等数据库检索真实文献。*

       

背景信息

The GFRA1 (GDNF Family Receptor Alpha-1) antibody is a tool used to detect and study the GFRA1 protein, a key component of the receptor complex for glial cell line-derived neurotrophic factor (GDNF). GFRA1 belongs to the GFRα family of glycosylphosphatidylinositol (GPI)-anchored co-receptors that mediate signaling of GDNF ligands, which are critical for neuronal survival, differentiation, and maintenance. Specifically, GFRA1 binds GDNF and partners with the RET receptor tyrosine kinase to activate downstream pathways like MAPK and PI3K/AKT, influencing cell proliferation, migration, and apoptosis. This receptor-ligand system is vital in nervous system development, kidney morphogenesis, and spermatogenesis.

Antibodies targeting GFRA1 are widely used in research to investigate its expression and function in tissues, particularly in neurodegenerative diseases (e.g., Parkinson’s) and cancers (e.g., neuroblastoma, breast cancer), where dysregulated GFRA1 signaling may contribute to pathogenesis. They enable techniques like immunohistochemistry, Western blotting, and flow cytometry. Studies also explore GFRA1's role in stem cell niches and regenerative therapies. Available as monoclonal or polyclonal antibodies, they are typically validated for specificity across species (human, mouse, rat). Understanding GFRA1 dynamics aids in developing therapeutic strategies targeting GDNF pathways for neurological disorders or oncology.

       
GFRA1抗体;GFRA1;GFRA1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

GFRA1抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价