Rabbit Polyclonal GDF1 Antibody

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P03982(GDF1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

The Growth Differentiation Factor 1 (GDF1) antibody is a research tool targeting GDF1. a secreted glycoprotein within the transforming growth factor-beta (TGF-β) superfamily. GDF1 plays critical roles in embryonic development, particularly in establishing left-right asymmetry and regulating cellular differentiation. It functions as a nodal signaling pathway co-ligand, forming heterodimers with other TGF-β members like BMPs to activate SMAD-dependent signaling cascades. This interaction is vital for tissue patterning, organogenesis, and maintaining tissue homeostasis.

GDF1 antibodies are widely used to detect and quantify GDF1 expression in studies involving Western blotting, immunohistochemistry, and immunofluorescence. They enable researchers to investigate GDF1's spatial-temporal expression patterns and its involvement in developmental disorders, cardiovascular diseases, and cancer. For instance, dysregulated GDF1 has been linked to congenital heart defects, neural tube anomalies, and tumor progression, where it may exhibit dual roles as either a tumor promoter or suppressor depending on cellular context.

Despite its significance, GDF1's mechanisms remain partially understood, partly due to its complex post-translational processing and context-dependent interactions. The antibody thus serves as a key reagent in elucidating GDF1's biological functions and therapeutic potential. Validated antibodies ensure specificity for both precursor and mature GDF1 forms, supporting advancements in developmental biology and disease pathology research.