4-氰基-N-三氟甲氧基吡啶三氟甲酰亚胺

4-Cyano-N-trifluoromethoxypyridinium triflimide is a versatile reagent for radical trifluoromethoxylation, enabling the direct introduction of the trifluoromethoxy group (-OCF3) under visible-light photoredox catalysis. It is used for regioselective C–H functionalization of arenes1 and α-trifluoromethoxylation of ketones2, offering high chemoselectivity and efficiency. The reagent is particularly valuable for functionalizing bioactive molecules, including natural products and pharmaceutical precursors. It is bench-stable and thermally robust up to 240°C, can be stored under ambient conditions, and is compatible with a wide range of functional groups.

Synonyms: 4-cyano-N-trifluoromethoxypyridinium triflimide; 4-cyano-1-(trifluoromethoxy)pyridinium bis(trifluoromethanesulfonimide); 4-cyano-1-(trifluoromethoxy)pyridin-1-ium bis((trifluoromethyl)sulfonyl)amide; bis(trifluoromethylsulfonyl)azanide;1-(trifluoromethoxy)pyridin-1-ium-4-carbonitrile; N-trifluoromethoxy-4-cyanopyridinium triflimide