辰辉创聚生物®Nebulabio 提供覆盖多种类，多靶点的生物活性重组蛋白，能够提供一系列与 P53 相关蛋白产品。我们的产品具备完整且准确的氨基酸序列，经过了严格的质量检测流程，能够很好地满足科研工作者在基础细胞生物学机制探究、细胞信号通路研究等方面的需求。
p53 信号通路是一个复杂的生物信号网络，在细胞对 DNA 损伤的反应、细胞周期调控、细胞凋亡、代谢调节和基因组稳定性维护中发挥着重要作用。作为一种被誉为“基因组守护者”的肿瘤抑制蛋白，p53 以其在癌症预防中的关键作用而受到广泛关注。
从机制上来看，细胞内的应激信号通过翻译后修饰机制激活 p53 蛋白，使其作为转录因子启动细胞周期停滞、衰老或凋亡的程序。p53 反应基因所产生的转录网络与细胞内多种信号转导通路密切相互作用，同时也受到多种正负反馈回路的调节。此外，p53 通路与 Wnt-β-catenin、IGF-1-AKT、Rb-E2F、p38 MAP 激酶、细胞周期蛋白-CDK、p14/19 ARF 通路以及 G-PP2A 和 p73 基因产物等信号通路存在交互。
p53 信号通路的两种主要凋亡通路包括外源性通路和内源性通路。外源性通路涉及激活属于肿瘤坏死因子受体（TNFR）家族的“死亡”受体，这些受体通过形成促凋亡的死亡诱导信号复合物（DISC）激活 caspase 酶，如 Caspase-8 和 Caspase-3。内源性通路则是通过 Bcl-2 家族蛋白的调控来实现的，这些蛋白质通过调节线粒体外膜的通透性，从而影响细胞凋亡的过程。
产品列表如下：
| 目录号 | 品名 | 靶点 | 物种 | 表达系统 |
| NBL-243709 | NebuSelect™ Recombinant Human CDK1, 1-297aa, His-tag | Cdk1;CDC2 | Human | Insect Cells |
| NBL-243273 | NebuSelect™ Recombinant Human AKT1, 1-480aa, His-tag | AKT1 | Human | Insect Cells |
| NBL-248860 | NebuSelect™ Recombinant Human AKT3, GST-tag | AKT3 | Human | Insect Cells |
| NBL-243362 | NebuSelect™ Recombinant Human ARF1, 1-181aa, His-tag | ARF1 | Human | E.coli |
| NBL-243363 | NebuSelect™ Recombinant Human ARF3, 1-181aa, His-tag | ARF3 | Human | E.coli |
| NBL-244359 | NebuSelect™ Recombinant Human GATM, 38-423aa, His-tag | GATM;AGAT | Human | E.coli |
| NBL-247467 | NebuSelect™ Recombinant Human CCND2, His-tag | CCND2 | Human | E.coli |
| NBL-249167 | NebuSelect™ Recombinant Human CCNE1, His-GST-tag | CCNE1 | Human | Insect Cells |
| NBL-248705 | NebuSelect™ Recombinant Human CDK2, His-tag | CDK2 | Human | Insect Cells |
| NBL-244912 | NebuSelect™ Recombinant Human KRAS, 1-186aa, His-tag | KRAS | Human | E.coli |
| NBL-243461 | NebuSelect™ Recombinant Human BCAT2, 28-392aa, His-tag | BCAT2;BCATM | Human | E.coli |
| NBL-248978 | NebuSelect™ Recombinant Human NRAS, His-tag | NRAS | Human | E.coli |
| NBL-244333 | NebuSelect™ Recombinant Human GADD45A, 1-165aa, His-tag | GADD45A | Human | E.coli |
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