阿福拉纳；1093861-60-9；Afoxolaner 新品

产品描述

等级：活性药物成分（API）

分子式：C26H17ClF9N3O3

分子量：625.87000

规范：按照ChP/USP/EP建立企业标准

外观:粉

总杂质：不大于2.0%

纯度：不低于98%

残留溶剂：完全符合ICH Q3C要求

致突变杂质：完全符合ICH M8

亚硝胺评估：可用

粒度：可根据客户要求进行普通级或研磨/筛分

储存方法：室温

生产能力：商用

标准包装：1kg/袋，5kg/袋，或根据客户要求

产品用途

Afoxolaner用于治疗和控制狗的跳蚤和蜱虫感染。在被狗摄入后，阿伏奥利内会分布在狗的全身。当跳蚤或蜱虫叮咬狗时，它们会接触到这种药物，并在吸食血液时被杀死。

它作为一种拮抗剂作用于配体门控氯离子通道，特别是那些由神经递质γ -氨基丁酸（gaba受体）门控的通道。在氯离子通道调节剂中，异恶唑啉类与昆虫gaba门控氯离子通道内一个独特的靶点结合，从而阻断氯离子跨细胞膜的突触前和突触后转移。长时间的阿伏唑啉引起的过度兴奋导致中枢神经系统活动失控和昆虫和螨虫死亡。

联系方式

四川青木制药有限公司

四川省眉山市东坡区经济开发区东区顺江大道南段55号

国际营销部(International):

Email: sales@eastonpharma.cn 

Tel: 028-87827187

国内营销部(Mainland)：

李经理 13880480517   

杨经理 15982276454

Product Description

Grade: Active Pharmaceutical Ingredient(API)

ChemicalName: 4-[(5R)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]naphthalene-1-carboxamide

Molecular Formula: C26H17ClF9N3O3

Molecular Weight: 625.87000

Specification: Enterprise Standard established according to ChP/USP/EP

Appearance: Powder

Total impurities: not more than 2.0%

Purity: not less than 98%

Residual Solvents: fully comply with ICH Q3C

Mutagenic impurities: fully comply with ICH M8

Nitrosamine assessment: available

Particle size: regular grade or milling/sieving according to customer’s requirement.

Storage: Room temperature

Production capacity: Commercial

Standard Package: 1kg/bag, 5kg/bag, or according to the customer’s requirement.

Applications 

Afoxolaner is used to treat and control flea and tick infestations in dogs. After being ingested by a dog, afoxolaner is distributed throughout the dog’s body. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal.

It acts as an antagonist at ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA-receptors). Isoxazolines, among the chloride channel modulators, bind to a distinct and unique target site within the insect GABA-gated chloride channels, thereby blocking the pre- and post-synaptic transfer of chloride ions across cell membranes. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines.

Contact Information

Sichuan Qingmu Pharmaceutical Co., Ltd.

Add: No. 55, South Shunjiang Avenue, East Economic Development Zone, Dongpo District, Meishan City, Sichuan, 620036, China

International Marketing Department: 

Email: sales@eastonpharma.cn 

Tel: 0086-28-87827187