单克隆猴痘E8L抗体——ACROBiosystems百普赛斯

Monoclonal Anti-Monkeypox-E8L Antibody, Human IgG1 (1C12) (MALS verified) 

抗体来源（Source）

Monoclonal Anti-Monkeypox-E8L Antibody, Human IgG1 (1C12) is a chimeric monoclonal antibody recombinantly expressed from HEK293, which combines the variable region of a mouse monoclonal antibody with Human constant domain.

克隆号（Clone）

1C12

亚型（Isotype）

Human IgG1 | Human Kappa

偶联（Conjugate）

Unconjugated

抗体类型（Antibody Type）

Recombinant Monoclonal

种属反应性（Reactivity）

Virus

免疫原（Immunogen）

Recombinant Monkeypox virus (strain Zaire-96-I-16) E8 derived from human 293 cells.

特异性（Specificity）

This product is a specific antibody specifically reacts with E8L (MPXV).

应用（Application）

纯度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

纯化（Purification）

Protein A purified / Protein G purified

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

猴痘是由猴痘病毒引起的一种罕见的人畜共患病，猴痘病毒已成为最严重的正痘病毒，由复杂的双链DNA组成。猴痘的发病机制是病毒从呼吸道粘膜侵入人体，在淋巴细胞中繁殖，并进入血液，产生短暂的性病毒血症。病毒在细胞中繁殖后，细胞可以侵入血液并传播到全身皮肤，引起病变。E8L可以与细胞表面的硫酸软骨素结合，使病毒颗粒附着在靶细胞上。