新冠病毒中和抗体Spike RBD——ACROBiosystems百普赛斯

Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1 (AS35)

抗体来源（Source）

Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1 (AS35) (SAD-S35) is isolated from a SARS-CoV-2 infected patient and is recombinantly produced from human 293 cells (HEK293). This antibody recognizes the SARS-CoV-2 Spike Protein RBD domain and inhibits the interaction between SARS-CoV-2 RBD and ACE2 with an IC50 of 1.47 μg/mL using SARS-CoV-2 Inhibitor Screening Kit.Pseudovirus assay shows that this antibody has potent neutralizing activity against pseudovirus bearing SARS-CoV-2 Spike protein.

克隆号（Clone）

AS35

亚型（Isotype）

Human IgG1 | Kappa

偶联（Conjugate）

Unconjugated

抗体类型（Antibody Type）

Recombinant Monoclonal

种属反应性（Reactivity）

Virus

特异性（Specificity）

This product is a specific antibody against SARS-CoV-2 Spike protein RBD domain. No cross-reactivity is detected with Spike protein RBD domain of other coronaviruses, including SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1.

应用（Application）

纯度（Purity）

>95% as determined by SDS-PAGE.

纯化（Purification）

Protein A purified / Protein G purified

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

冠状病毒可以通过与人ACE2受体相互作用感染人呼吸道上皮细胞。刺突蛋白是一种大的I型跨膜蛋白，含有两个亚基S1和S2。S1主要包含一个受体结合结构域（RBD），负责识别细胞表面受体。S2包含膜融合所需的基本元件。S蛋白在诱导中和抗体和T细胞反应以及保护性免疫中起着关键作用。