重组人TFPI2蛋白-ACROBiosystems百普赛斯

TFPI-2产品信息

英文名称：DNA-(apurinic or apyrimidinic site) lyase

中文名称：DNA-(无嘌呤或无嘧啶位点)裂合酶

靶点别称：TFPI2,PP5,REF1

物种：Human

标签：His Tag

属性：Protein

标记：Unconjugated

表达区间及表达系统（Source）

Human TFPI-2, His Tag (TF2-H5227) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Lys 213 (Accession # NP_006519.1).

Predicted N-terminus: Asp 23

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 22.7 kDa. The protein migrates as 26-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

组织因子途径抑制剂2（TFPI 2）也称为胎盘蛋白5（PP5）和视网膜色素上皮细胞因子1（REF 1），是Kunitz型丝氨酸蛋白酶抑制剂家族的成员，是组织因子途径抑制物（TFPI）的结构同源物。TFPI2在足月胎盘中含量很高，在晚期妊娠时广泛表达于脐静脉内皮细胞、肝脏、胎盘、心脏、胰腺和母体血清中。TFPI 2可能在调节纤溶酶介导的基质重塑中发挥作用。抑制胰蛋白酶、纤溶酶、VIIa/组织因子和弱Xa因子，对凝血酶没有影响。TFPI-2合成减少与许多病理生理过程有关，如炎症、血管生成、动脉粥样硬化、视网膜变性和肿瘤生长/转移。