重组人FKBP4蛋白-ACROBiosystems百普赛斯

Human FKBP4 / FKBP52 Protein, His,PA Tag

分子别名（Synonym）

FKBP4,FKBP52

表达区间及表达系统（Source）

Human FKBP4, His,PA Tag (FK4-H52Q3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 459 (Accession # AAH01786).

Predicted N-terminus: Met 1

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus, followed by a PA tag, and has a calculated MW of 55.1 kDa. The reducing (R) protein migrates as 60 kDa in SDS-PAGE.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

肽基脯氨酰顺反异构酶FKBP4（PPIase FKBP4）也称为亲免疫蛋白FKBP52。FKBP4是亲免疫蛋白家族的成员，在免疫调节和涉及蛋白质折叠和运输的基本细胞过程中发挥作用。FKBP4与FK506结合蛋白1A（FKBP1A）在结构和功能上具有高度相似性，但与FKBP1A不同，该蛋白与FK506复合时没有免疫抑制活性。FKBP4与干扰素调节因子-4相互作用，在B和T淋巴细胞的免疫调节基因表达中起着重要作用。