重组人KREMEN1/KRM1蛋白-ACROBiosystems百普赛斯

Human Kremen-1 protein, Fc Tag

分子别名（Synonym）

KREMEN1,KRM1

表达区间及表达系统（Source）

Human Kremen-1, Fc Tag (KR1-H5253) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Thr 392 (Accession # Q96MU8-1).

Predicted N-terminus: Arg 21

蛋白结构（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 67.4 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

Kremens是Dickkopf 1（Dkk1）的高亲和力受体，通过下调低密度脂蛋白受体相关蛋白6（LRP6）来调节Wnt/β-catenin信号通路。Kremen1被认为是脊椎动物通过LRP6调节经典Wnt信号传导的膜复合物的一个组成部分。此外，KREMEN1（KRM1）也被确定为柯萨奇病毒A10（CV-A10）的功能性受体，柯萨奇病毒是手足口病（HFMD）的病原体。