重组人JAB1/COPS5蛋白-ACROBiosystems百普赛斯

Human JAB1 / COPS5 Protein, Fc Tag

分子别名（Synonym）

JAB1,COPS5

表达区间及表达系统（Source）

Human JAB1 Protein, Fc Tag (JA1-H5553) is expressed from Baculovirus-Insect cells. It contains AA Ala 2 - Ser 334 (Accession # Q92905-1).

Predicted N-terminus: Ala 2

蛋白结构（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 63.9 kDa. The protein migrates as 33 kDa and 64-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

Jab1，也称为CSN5，是（COP9）信号体复合体（CSN）的一个组成部分，据报道参与细胞增殖、细胞周期进程和肿瘤发生的调节。作为COP9信号体复合体的一个组成部分，Jab1可以相互调节MED1的稳定性和转录活性，可能是介导HER2+肿瘤侵袭性表型的MED1直接靶基因。