重组人KIR2DL3/CD158b2蛋白-ACROBiosystems百普赛斯

KIR2DL3产品信息

英文名称：Killer cell immunoglobulin-like receptor 2DL3

中文名称：杀伤细胞免疫球蛋白样受体2DL3

靶点别称：KIR2DL3,CD158b2

物种：Human

标签：Fc Tag

属性：Protein

标记：Unconjugated

表达区间及表达系统（Source）

Human KIR2DL3, Fc Tag (KI3-H5258) is expressed from human 293 cells (HEK293). It contains AA His 22 - His 245 (Accession # P43628-1).

Predicted N-terminus: His 22

蛋白结构（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 51.0 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

杀伤细胞免疫球蛋白样受体2DL3（KIR2DL3）也被称为CD158抗原样家族成员B2、KIR-023GB、杀伤抑制性受体cl2-3、MHC I类NK细胞受体、NKAT2a、NKAT2b、自然杀伤相关转录物2、p58自然杀伤细胞受体克隆cl-6、p58.2 MHC I类特异性NK受体、CD158b2和KIR2DL三，它是一种单程I型膜蛋白，属于免疫球蛋白超家族。KIR2DL3是自然杀伤（NK）细胞上HLA-C等位基因（HLA-Cw1、HLA-Cw3和HLA-Cw7）的受体。KIR2DL3可以抑制NK细胞的活性，从而防止细胞裂解。