重组人CCL24蛋白-ACROBiosystems百普赛斯

CCL24产品信息

英文名称：Chemokine (C-C Motif) Ligand 24

中文名称：趋化因子CCL24

靶点别称：CCL24

物种：Human

标签：His Tag

属性：Protein

标记：Unconjugated

表达区间及表达系统（Source）

Human CCL24, His Tag (CC4-H52H1) is expressed from human 293 cells (HEK293). It contains AA Val 27 - Cys 119 (Accession # O00175).

Predicted N-terminus: Val 27

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 12.3 kDa. The protein migrates as 18-21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-HPLC.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

C-C基序趋化因子配体24（CCL24），也称为eotaxin2，属于类似MCP-1的CC趋化因子，主要趋化嗜酸性粒细胞。CCL24可以促进嗜酸性粒细胞与内皮细胞的分离，然后与其唯一的配体结合，促进嗜酸性细胞进入组织。CCL24最初在嗜酸性粒细胞中没有发现，但最初是从单核细胞中分离出来的。最近，发现哮喘患者支气管上皮细胞中CCL24的表达增加。CCL24通过CCR3受体（C-C趋化因子受体3型）促进免疫细胞运输和活化以及促纤维化活性。CCL24和CCR3都参与肺部和皮肤炎症和纤维化。