重组人LAG1蛋白-ACROBiosystems百普赛斯

CCL4产品信息

英文名称：C-C motif chemokine 4

中文名称：趋化因子CCL4

靶点别称：CCL4,LAG1

物种：Human

标签：His Tag

属性：Protein

标记：Unconjugated

表达区间及表达系统（Source）

Human CCL4 Protein, His Tag (CC4-H51H3) is expressed from E. coli cells. It contains AA Ala 24 - Asn 92 (Accession # P13236-1).

Predicted N-terminus: Met

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 9.7 kDa.

制剂（Formulation）

Please contact us for detailed information.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

CCL4，也称为MIP-1β，是一种具有炎症和趋化动力学特性的单因子。与CCR5绑定。CD8+T细胞产生的主要HIV抑制因子之一。重组MIP-1β诱导对HIV-1、HIV-2和猿猴免疫缺陷病毒（SIV）不同毒株的剂量依赖性抑制。加工形式MIP-1-β（3-69）保留了诱导趋化因子受体CCR5表面表达下调和抑制CCR5介导的HIV-1进入T细胞的能力。MIP-1β（3-69）也是CCR1和CCR2亚型B的配体。