重组人KIR2DL5/CD158f蛋白-ACROBiosystems百普赛斯

Human KIR2DL5 / CD158f Protein, Fc Tag

分子别名（Synonym）

KIR2DL5,CD158f

表达区间及表达系统（Source）

Human KIR2DL5 / CD158f Protein, Fc Tag (KIA-H5255) is expressed from human 293 cells (HEK293). It contains AA His 22 - His 240 (Accession # Q8N109-1).

Predicted N-terminus: His 22

蛋白结构（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 50 kDa. The protein migrates as 63-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris,100 mM Glycine,25 mM Arg,150 mM NaCl,pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

杀伤细胞免疫球蛋白样受体2DL5（KIR2DL5）属于免疫球蛋白超家族，是NK细胞的抑制性受体。KIR2DL5由两个同源基因编码，这两个基因显示拷贝数变异和等位基因多态性——KIR2DL5A和KIR2DL5B，其结构域仅变化2个氨基酸，信号肽仅变化1个氨基酸。KIR2DL5和KIR2DL4形成一个亚家族，其细胞质尾部比其他KIR更长，每个都有一个D0和一个D2型Ig样结构域。