重组人ProS1蛋白-ACROBiosystems百普赛斯

ProS1产品信息

英文名称：Prostate-specific antigen

中文名称：前列腺特异性抗原

靶点别称：ProS1

物种：Human

标签：His Tag

属性：Protein

标记：Unconjugated

表达区间及表达系统（Source）

Human ProS1 Protein, His Tag (PR1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Val 284 - Ser 676 (Accession # P07225).

Predicted N-terminus: Val 284

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 45.6 kDa. The protein migrates as 53-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

ProS1是白细胞免疫球蛋白样受体（LIR）家族的成员，该家族存在于染色体区域19q13.4的基因簇中。编码的蛋白质属于LIR受体的B亚家族，其包含两个或四个细胞外免疫球蛋白结构域、一个跨膜结构域和两到四个基于细胞质免疫受体酪氨酸的抑制基序（ITIM）。受体在免疫细胞上表达，与抗原呈递细胞上的MHC I类分子结合，并传递抑制免疫反应刺激的负信号。它被认为可以控制炎症反应和细胞毒性，以帮助集中免疫反应并限制自身反应性。已发现该基因存在编码不同异构体的多种转录变体。