重组人LRRC4蛋白-ACROBiosystems百普赛斯

Human LRRC4 Protein, His Tag

分子别名（Synonym）

LRRC4,NGL-2,BAG,NAG14

表达区间及表达系统（Source）

Human LRRC4, His Tag (LR4-H5221) is expressed from human 293 cells (HEK293). It contains AA Ala 39 - Lys 527 (Accession # AAI11562.1).

Predicted N-terminus: Ala 39

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 55.8 kDa. The protein migrates as 90-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

LRRC4（富含亮氨酸重复序列/LRR的糖蛋白4）、LRRC4B和LRRC4C是诱导兴奋性突触形成的LRR蛋白家族的突触后粘附分子。LRRC4也被称为脑肿瘤相关蛋白BAG、Netrin-G2配体（NGL-2）、鼻咽癌相关基因14蛋白（G14），其含有1个Ig样（免疫球蛋白样）结构域和9个LRR（富含亮氨酸）重复序列、1个LRRCT结构域、1个LRONT结构域。LRRC4/NGL-2在脑中特异性表达。LRRC4/NGL-2通过募集突触前和突触后蛋白来调节兴奋性突触的形成。LRRC4/NGL-2组织树突的膜/通路特异性分化。LRRC4/NGL-2在听觉突触反应中起着重要作用，并参与了胶质瘤的抑制。