重组人IGFBP1蛋白-ACROBiosystems百普赛斯

Human IGFBP-1 Protein, His Tag (MALS verified)

分子别名（Synonym）

IGFBP1,PP12,IBP1

表达区间及表达系统（Source）

Human IGFBP-1 Protein, His Tag (IG1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Asn 259 (Accession # P08833).

Predicted N-terminus: Ala 26

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 27.2 kDa. The protein migrates as 32-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

胰岛素样生长因子结合蛋白1（IGFBP1）也被称为胎盘蛋白12（PP12），它包含一个IGFBP N末端结构域和一个甲状腺球蛋白1型结构域。IGFBP1可以结合胰岛素样生长因子（IGFs）I和II，并在血浆中循环。IGFBP1的结合可以延长IGFs的半衰期，并改变它们与细胞表面受体的相互作用。此外，IGFBP1可以促进细胞迁移。编码不同异构体的交替转录剪接变体已被表征。