重组人STMN1/Stathmin蛋白-ACROBiosystems百普赛斯

Stathmin 1产品信息

英文名称：Stathmin

中文名称：Stathmin蛋白

靶点别称：STMN1,Stathmin 1,C1orf215,LAP18,OP18

物种：Human

标签：His Tag

属性：Protein

标记：Unconjugated

表达区间及表达系统（Source）

Human Stathmin 1, His Tag (ST1-H5149) is expressed from E. coli cells. It contains AA Ala 2 - Asp 149 (Accession # NP_981946).

Predicted N-terminus: Met

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 18.1 kDa. The protein migrates as 18 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

Stathmin（STMN1）是Stathmin家族的成员，也被称为白血病相关磷蛋白p18、癌蛋白18（Op18）、磷蛋白p19（pp19）、蛋白Pr22和pp17，其中含有一个SLD（Stathmin样）结构域。STMN1作为微管动力学的重要调节蛋白的功能已得到很好的表征。Stathmin（STMN1）与两个二聚体α，β-微管蛋白分子相互作用，形成一个紧密的三元复合物，称为T2S复合物。一摩尔STMN1通过stathmin样结构域（SLD）与两摩尔微管蛋白二聚体结合。当STMN1将微管蛋白螯合到T2S复合物中时，微管蛋白变得不可聚合。没有微管蛋白聚合，就没有微管组装。STMN1还通过直接作用于微管末端来促进微管解体。