重组人Contactin-2/CNTN2蛋白-ACROBiosystems百普赛斯

Human Contactin-2 / Tag1 / CNTN2 Protein, His Tag

分子别名（Synonym）

Contactin-2，Tag1，CNTN2

表达区间及表达系统（Source）

Human Contactin-2, His Tag (CN2-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 31 - Asn 1012 (Accession # NP_005067.1).

Predicted N-terminus: Ser 31

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 108.3 kDa. The protein migrates as 116-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

接触蛋白2也称为CNTN2、TAX1（瞬时表达的轴突糖蛋白）、TAG1（瞬时轴突糖蛋白）和轴突蛋白1，是免疫球蛋白超家族的成员。CNTN2由六个Ig样结构域和四个纤维连接蛋白III型结构域组成，通过糖基磷脂酰肌醇（GPI）锚定在膜上，而可溶性形式可以通过GPI特异性磷脂酶释放。作为一种神经细胞粘附分子，由发育中的中枢神经系统和PNS中的一部分神经元群体表达，CNTN2通过与各种粘附分子（包括NgCAM、NrCAM、NCAM和神经康）的亲同或异亲接触介导细胞间相互作用。它是一种糖基磷脂酰肌醇（GPI）锚定的神经元膜蛋白，起着细胞粘附分子的作用。它可能在发育中的神经系统中轴突连接的形成中发挥作用。它也可能参与神经胶质肿瘤的发生，并可能为治疗干预提供潜在的靶点。