重组人CCR7蛋白-ACROBiosystems百普赛斯

Human CCR7 Full Length Protein, His,Flag Tag (Detergent)

分子别名（Synonym）

BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1

表达区间及表达系统（Source）

Human CCR7 Full Length Protein, His,Flag Tag (CC7-H52D3) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Pro 378 (Accession # P32248).

Predicted N-terminus: Gln 25

蛋白结构（Molecular Characterization）

The protein has a calculated MW of 58.9 kDa.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>85% as determined by SDS-PAGE.

制剂（Formulation）

This product is not suitable for cell based experiments due to cytotoxicity of LMNG.

LMNG and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumastance should you remove LMNG and CHS.

LMNG/CHS buffer (LG-13) is sold separately and not included in protein, and please contact us if you need the buffer.
If glycerol is not compatible to your application, remove glycerol just before immediate experiment, and NEVER store glycerol-free protein solution.

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, LMNG, CHS, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

The product MUST be stored at -70°C or lower upon receipt;

-70°C for 3 months under sterile conditions.

背景（Background）

单克隆抗体mAb-729与人CC趋化因子受体CCR7反应。该基因编码的蛋白质是G蛋白偶联受体家族的成员。该受体被鉴定为由爱泼斯坦-巴尔病毒（EBV）诱导的基因，被认为是EBV对B淋巴细胞影响的介质。这种受体在各种淋巴组织中表达，并激活B和T淋巴细胞。它已被证明可以控制记忆T细胞向炎症组织的迁移，并刺激树突细胞成熟。趋化因子（C-C基序）配体19（CCL19/ECL）已被报道为该受体的特异性配体。由该受体介导的信号调节淋巴结中的T细胞稳态，也可能在T细胞的活化和极化以及慢性炎症发病机制中发挥作用。