重组人Serpin F1蛋白-ACROBiosystems百普赛斯

Serpin F1产品信息

英文名称：Pigment epithelium-derived factor

中文名称：色素上皮衍生因子

靶点别称：Serpin F1

物种：Human

标签：His Tag

属性：Protein

标记：Unconjugated

表达区间及表达系统（Source）

Human Serpin F1, His Tag (SE1-H5221) is expressed from human 293 cells (HEK293). It contains AA Gln 20 - Pro 418 (Accession # NP_002606).

Predicted N-terminus: Gln 20

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 45.2 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

erpin F1（SERPINF1）也被称为色素上皮衍生因子（PEDF）、细胞增殖诱导基因35蛋白（PIG35）。Serpin F1属于Serpin家族。Serpin F1在静止细胞中表达。PEDF具有多种功能，包括抗血管生成、抗肿瘤和神经营养特性。SERPINF1/PEDF抑制内皮细胞迁移。PEDF/SERPINF1抑制视网膜新生血管和内皮细胞增殖。PEDF还通过p38 MAPK通路或FAS/FASL通路负责内皮细胞的凋亡。PEDF还具有神经营养功能。