重组人KREMEN2蛋白-ACROBiosystems百普赛斯

Human Kremen-2 protein, His Tag

分子别名（Synonym）

KREMEN2, Kremen-2, KRM2, Dickkopf receptor 2,Kringle domain-containing transmembrane protein 2

表达区间及表达系统（Source）

Human Kremen-2, His Tag (KR2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 26 - Ala 364 (Accession # Q8NCW0-1).

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 38.0 kDa. The protein migrates as 45-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 0.2M Arginine, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

Kremen2（Krm2）作为经典Wnt/β-catenin信号通路的关键调节因子，在胚胎发育、骨形成和肿瘤发生中起着重要作用。Krm1及其同源Krm2具有结合Dkk1和抑制Wnt信号传导的能力，这两个过程之前都被证明依赖于细胞外结构域。先前的研究表明，Krm2可能参与胚胎发育、骨形成、神经脊形成和肿瘤发生，并可能是癌症分级的生物标志物和潜在的治疗靶点。