重组人ENPP2蛋白-ACROBiosystems百普赛斯

ENPP-2产品信息

英文名称：Ectonucleotide pyrophosphatase/phosphodiesterase 2

中文名称：核苷酸内焦磷酸酶/磷酸二酯酶2

靶点别称：ENPP-2

物种：Human

标签：His Tag

属性：Protein

标记：Unconjugated

表达区间及表达系统（Source）

Human ENPP-2, His Tag (EN2-H5241) is expressed from human 293 cells (HEK293). It contains AA Asp 49 - Ile 863 (Accession # NP_001035181).

Predicted N-terminus: His

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 94.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE).

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

Autotaxin也称为外核苷酸焦磷酸酶/磷酸二酯酶家族成员2（E-NPP 2或ENPP2）、细胞外溶血磷脂D（LysoPLD）、自身滑行素（ATX或ATX-X），属于核苷酸焦磷酸酶或磷酸二酯酶家庭。ENPP2包含两个SMB（somatomedin-B）域。ENPP2水解溶血磷脂，在细胞外液中产生溶血磷脂酸（LPA）。ENPP2可以作用于产生鞘氨醇-1-磷酸的鞘氨醇磷脂酰胆碱，这是一种细胞运动的调节剂。ENPP2可能通过百日咳毒素敏感的G蛋白刺激黑色素瘤细胞的迁移。