重组人CXCL16蛋白-ACROBiosystems百普赛斯

Human CXCL16 Protein, Fc Tag

分子别名（Synonym）

CXCLG16, SR-PSOX, SRPSOX, C-X-C motif chemokine ligand 16

表达区间及表达系统（Source）

Human CXCL16, Fc Tag (CX6-H5254) is expressed from human 293 cells (HEK293). It contains AA Asn 30 - Thr 205 (Accession # Q9H2A7-1).

蛋白结构（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 45.7 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

该基因编码的蛋白质是一种G蛋白偶联受体，具有七个跨膜结构域，属于CXC趋化因子受体家族。该家族还包括CXCR1、CXCR2、CXCR3、CXCR4、CXCR5和CXCR7。该基因映射到趋化因子受体基因簇，在几个T淋巴细胞亚群和骨髓基质细胞中表达。编码的蛋白质及其唯一配体趋化因子配体16（CCL16）是调节T淋巴细胞向各种外周组织（肝、脾红髓、肠、肺和皮肤）迁移的信号通路的一部分，并促进细胞与树突状细胞和成纤维网状细胞的相互作用。CXCR6/CCL16还控制驻留记忆T淋巴细胞在肺部不同部位的定位，并维持气道驻留记忆T细胞，这是抵抗呼吸道病原体的重要第一道防线。编码的蛋白质充当HIV-1和SIV与CD4结合进入靶细胞的进入辅助受体。