重组人CXCL2蛋白-ACROBiosystems百普赛斯

Human CXCL2 Protein, Fc Tag (MALS verified)

分子别名（Synonym）

C-X-C motif chemokine 2, Growth-regulated protein beta, Gro-beta, Macrophage inflammatory protein 2-alpha, MIP2-alpha, GRO2, GROB, MIP2A, SCYB2

表达区间及表达系统（Source）

Human CXCL2, Fc Tag (CX2-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 35 - Asn 107 (Accession # P19875).

Predicted N-terminus: Ala 35

蛋白结构（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 34.3 kDa. The protein migrates as 38-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

趋化因子（C-X-C基序）配体2（CXCL2）是属于CXC趋化因子家族的一种小细胞因子，也称为巨噬细胞炎性蛋白2α（MIP2α）、生长调节蛋白β（Groβ）和Gro癌基因-2（Gro-2）。CXCL2在氨基酸序列上与相关趋化因子CXCL1有90%的相同性。这种趋化因子由单核细胞和巨噬细胞分泌，对多形核白细胞和造血干细胞具有趋化作用。CXCL2通过与称为CXCR2的细胞表面趋化因子受体相互作用来动员细胞。与相关趋化因子一样，CXCL2也是一种强大的中性粒细胞趋化因子，并参与许多免疫反应，包括伤口愈合、癌症转移和血管生成。