重组人Nogo受体蛋白-ACROBiosystems百普赛斯

Human Nogo Receptor / NgR Protein, His Tag (SPR verified)

分子别名（Synonym）

Reticulon-4 receptor，Nogo-66 receptor

表达区间及表达系统（Source）

Human Nogo Receptor, His Tag (NOR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Cys 27 - Ser 447 (Accession # Q9BZR6).

Predicted N-terminus: Cys 27

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 47.2 kDa. The protein migrates as 63-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

Nogo受体/网织红蛋白-4受体在调节成人中枢神经系统的轴突再生和神经元可塑性中起着重要作用。在出生后的大脑发育中发挥作用。轴突在大脑中线的正常迁移和胼胝体的正常形成所必需的。保护运动神经元免于凋亡；抗凋亡的保护作用可能是通过与MAG的相互作用介导的。在皮质发育过程中，与RTN4和LINGO1协同作用，调节神经元前体细胞的运动。与其他家庭成员一样，它在限制大脑发育过程中形成的树突棘数量和突触数量方面发挥着作用。