重组人NGFR蛋白-ACROBiosystems百普赛斯

NGFR产品信息

英文名称：Low affinity neurotrophin receptor p75NTR

中文名称：低亲和力神经营养因子受体p75NTR

靶点别称：NGFR，TNFRSF16

物种：Human

标签：Fc Tag

属性：Protein，Cell

标记：Unconjugated

表达区间及表达系统（Source）

Human NGFR Protein, Fc Tag (NGR-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 29 - Asn 250 (Accession # P08138-1).

Predicted N-terminus: Lys 29

蛋白结构（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus

The protein has a calculated MW of 50.0 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>90% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

p75神经营养因子受体（p75NTR）最初被鉴定为神经营养因子（NGF R）的低亲和力受体。神经营养因子受体结合神经营养因子，包括神经生长因子、神经营养因子-3、脑源性神经营养因子和神经营养因子-4。所有神经营养因子都与p75NTR结合。这也包括未成熟的促神经营养因子形式。神经营养因子受体，包括p75NTR，负责确保发育中神经元的适当密度与靶比，将发育中更广泛的图谱细化为精确的连接。p75NTR参与促进神经元存活和神经元死亡的途径。