HXR9/917953-08-3/竞争性拮抗剂多肽HXR9

Product Name：HXR9

CAS No.：917953-08-3

Synonyms：竞争性拮抗剂多肽HXR9

Catalog No.：PYC-058

Description：HXR9 是一种细胞渗透性肽，由18个氨基酸组成，是 HOX/PBX 相互作用 (HOX/PBX interaction) 的竞争性拮抗剂。HXR9 拮抗 HOX 与第二转录因子 (PBX) 之间的相互作用，PBX 与旁系同源基因组 1 至 8 中的 HOX 蛋白结合。HXR9 选择性地减少细胞增殖并促进 HOXA/PBX3 基因高水平表达的细胞，例如 MLL 重排的白血病细胞中的细胞凋亡 (apoptosis)。

HXR9 is a cell permeable peptide composed of 18 amino acids and is a competitive antagonist of the HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and the second transcription factor (PBX), which binds to HOX proteins in paralogous genomes 1 to 8. HXR9 selectively reduces cell proliferation and promotes high-level expression of HOXA/PBX3 genes in cells, such as apoptosis in leukemia cells with MLL rearrangement.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Sequence(1-letter code)	WYPWMKKHHRRRRRRRRR
Sequence(3-letter code)	H-Trp-Tyr-Pro-Trp-Met-Lys-Lys-His-His-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH
Peptide Structure
Molecular Formula	C119H193N53O20S1
Molecular Weight	2718.21

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