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网站主页 (E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE 化合物 Tezacitabine
  • 化合物 Tezacitabine|T60401|TargetMol

化合物 Tezacitabine|T60401|TargetMol

Tezacitabine
130306-02-4
￥22500 25mg 起订
￥12800 10mg 起订
上海 更新日期：2025-11-17

TargetMol中国（陶术生物）

VIP4年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 Tezacitabine
英文名称：
Tezacitabine
CAS号：
130306-02-4
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T60401

Product Introduction

Bioactivity

名称Tezacitabine
描述Tezacitabine is a cytostatic and cytotoxic antimetabolite. Tezacitabine is a nucleoside analogue characterized by a dual mechanism of action. Tezacitabine irreversibly inhibits ribonucleotide reductase and can be incorporated into DNA during replication or repair, resulting in DNA chain termination. Tezacitabine blocks tumor cells in G1 and S phases of the cell cycle and induces apoptotic cell death. Tezacitabine has the potential to treat leukemia and solid tumors[1][2].
体外活性Tezacitabine (0.01-10 μM; 24 hours; CCRF-SB, KG-1, Jurkat, COLO-205, MCF-7 and PC-3 cells) treatment leads to the G1 and S-phase leaky block of the cell cycle [1]. Tezacitabine (0.01-10 μM; 24 hours; CCRF-SB, KG-1, Jurkat, COLO-205, MCF-7 and PC-3 cells) treatment concentration-dependently apoptosis the cells by the caspase 3/7 pathway[1]. Tezacitabine has highly cytostatic and cytotoxic properties. The cytotoxic effect of tezacitabine is manifested not only in apoptosis but also in changes in protein metabolism[1]. Cell Cycle Analysis [1] Cell Line: CCRF-SB, KG-1, Jurkat, COLO-205, MCF-7 and PC-3 cells Concentration: 0.01 μM, 0.1 μM, 1.0 μM, and 10 μM Incubation Time: 24 hours Result: Induced leaky block of the G1 (at concentrations higher than 10 nM) and S-phase (at low concentration) of the cell cycle. Apoptosis Analysis [1] Cell Line: CCRF-SB, KG-1, Jurkat, COLO-205, MCF-7 and PC-3 cells Concentration: 0.01 μM, 0.1 μM, 1.0 μM, and 10 μM Incubation Time: 24 hours Result: Concentration-dependently induced apoptotic death of cells by the caspase 3/7 pathway.
体内活性Tezacitabine (100 mg/kg; intraperitoneal injection; daily; female nude mice) treatment inhibits the growth of tumors in HCT 116 tumor xenografts [2]. Animal Model: Female nude mice (7-9-week-old) injected with HCT 116 cells [2] Dosage: 100 mg/kg Administration: Intraperitoneal injection; daily; 14 days Result: Tumor growth in HCT 116 tumor xenografts is inhibited.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
相关产品Guanidine hydrochloride | Cysteamine hydrochloride | Alginic acid | Metronidazole | Dextran sulfate sodium salt (MW 5000) | Citric Acid Triammonium | Stavudine | Adenine | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Thymidine | Sodium 4-phenylbutyrate
Tezacitabine|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (13年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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