化合物 PMX 205|T12506L|TargetMol

PMX 205
514814-49-4

￥6490 1mg 起订

上海更新日期：2024-09-30

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 PMX 205

英文名称：: PMX 205

CAS号：: 514814-49-4

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

产品类别：: 抑制剂

货号：: T12506L

Product Introduction

Bioactivity

名称	PMX 205
描述	PMX 205 is an effective complement antagonist of the C5a receptor.
体外活性	In the MTT assay, in 24 h plate, it shows that all groups are significant when compared with negative control group. For the PMX 205 group, the value recorded is between 0.09893 to 0.2465, EP54 group, 0.02724 to 0.1748, and Tamoxifen group, the value recorded in between 0.09880 to 0.2464. Only one group shows a significant result for the 72 h plate, PMX 205 (antagonist group) with the value recorded in between 0.02136 to 0.5322. Only two groups show a significant result for the 48 h plate of incubation time, which are PMX 205 and Tamoxifen. The values recorded are between 0.04987 to 0.3273 and 0.5777 to 0.8551 respectively [1].
体内活性	PMX 205 (1 mg/kg/day; SOD1G93A rats; p.o.) from two-time points (days 28 and 70) before the onset of major clinical symptoms. Both treatment groups have a significant extension in survival time compared with untreated rats (p=0.022, day 28; p=0.015, day 70), with no clear differences in outcomes between the two treatment regimens. PMX 205-treated animals also display reduced levels of astroglial proliferation in the lumbar spinal cord. Animals treated with PMX 205 (1 mg/kg/day, oral) show a significant extension of survival time and a reduction in end-stage motor scores, as compared with vehicle-treated rats. Tg2576 mice are treated with PMX 205 (PMX205) at 20 μg/mL in the drinking water (n=17) from 12 to 15 mo of age, the time frame at which there is a rapid accumulation of amyloid deposits in these animals. Untreated Tg2576 animals (n=11) are used as controls. After 3 mo, animals treated with PMX 205 show significantly less fibrillar plaque load (thioflavine reactivity) than do untreated animals. PMX 205 also significantly reduces hyperphosphorylated tau (69%) in 3×Tg mice [2][3].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
关键字	PMX 205 \| PMX205 \| PMX-205

PMX 205|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务