化合物 Ro-24-4736|T16768|TargetMol

Ro-24-4736
125030-71-9

￥16000 25mg 起订

￥27500 100mg 起订

￥21800 50mg 起订

上海更新日期：2025-11-17

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 Ro-24-4736

英文名称：: Ro-24-4736

CAS号：: 125030-71-9

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

产品类别：: 抑制剂

货号：: T16768

Product Introduction

Bioactivity

名称	Ro-24-4736
描述	Ro 24-4736 is an effective and selective platelet-activating factor antagonist.
体外活性	Ro 24-4736 competes with [3H]PAF for its receptor site on dog platelets (IC50: 9.8±1.0 nM). Ro 24-4736 selectively inhibits PAF-induced aggregation of guinea pig, dog, and human platelets with concentration dependence [1].
体内活性	Ro 24-4736 is markedly superior in terms of p.o. potency, bioavailability, and p.o. duration of action in comparison with other PAF antagonists evaluated in this guinea pig model. Ro 24-4736 is a new platelet-activating factor antagonist. Ro 24-4736 displays no inhibitory activity toward the bronchoconstrictor effects of leukotriene D4 or histamine. Ro 24-4736 dose-dependently inhibits in vivo bronchoconstriction (ID50: 0.006-mg/kg p.o.) and ex vivo platelet aggregation (ID50: 0.004 mg/kg; p.o.) induced by PAF in guinea pigs. Time course studies display a complete blockade of PAF-induced platelet aggregation (ex vivo) up to 8 hr after a single p.o. the dose of 0.03 mg/kg as well as a long duration of action in vivo (30 hr). The in vivo PAF antagonistic activity is specific because even at high p.o. doses (up to 10 mg/kg). Studies are also performed with Ro 24-4736 in additional in vivo models. When administered p.o. to sensitized guinea pigs, the drug attenuates inhaled antigen-induced airway hyper-reactivity without effect on bronchoalveolar lavage leukocyte accumulation. The tissue distribution of the 14C-label in male rats following a single intravenous dose of 1.0 mg/kg of 14C-Ro 24-4736 indicates appreciable uptake by the liver, kidney, heart, and gastrointestinal tract. Peak plasma and tissue concentrations are seen at 5 minutes after dosing except for the small intestine (4 hrs) and abdominal fat, stomach, and large intestine (4 hrs). At 48 hours, only 3.5% of the dose is present in the tissues, and 6.1% in the lumen of the gastrointestinal tracts [1][2].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
关键字	Ro-24-4736 \| Ro244736 \| Ro 24 4736 \| PAF
相关产品	48740 RP \| Rupatadine Fumarate \| Rupatadine \| Cedrol \| SDZ-62-434 \| Ginkgolide B \| PAF C-18 \| Dersalazine \| (Rac)-Modipafant \| CP 96021 \| 2-Acetylbenzoic acid \| Rocepafant

Ro-24-4736|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(13年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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