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  • 化合物 TRi-1|T5481|TargetMol

化合物 TRi-1|T5481|TargetMol

TRi-1
246020-68-8
￥568 1mg 起订
￥837 2mg 起订
￥1490 5mg 起订
上海 更新日期：2024-09-30

TargetMol中国（陶术生物）

VIP3年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 TRi-1
英文名称：
TRi-1
CAS号：
246020-68-8
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
98.4%
产品类别：
抑制剂
货号：
T5481

Product Introduction

Bioactivity

NameTRi-1
DescriptionTRi-1 is irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy
Animal ResearchFox Chase male SCID mice were treated once with TRi-1 (0.7 to 10 mg/kg) or TRi-2 (0.5 to 20 mg/kg) via intravenous injections, and mouse health status was observed for up to 72 hours. For repeateddose toxicity studies with tumor-bearing animals, mice were first inoculated with 1*10^6 FaDu cells in phosphate-buffered saline at a preshaved region located at the anterior lateral thoracic wall . After 13 days of growth, tumors were measured by calipers, and treatments were initiated. Mice were injected with TRi-1 (10 mg/kg), TRi-2 (15 mg/kg), auranofin (10 mg/kg), or vehicle a total of nine times during a 5-day span via intravenous tail injection. Upon the final day of dosing, injections were performed subcutaneously due to hematomas in several of the mice at the tail injection site. Mouse health status was monitored daily, weight was measured, and tumor volume was recorded from caliper measurements.
In vitroTRi-1在抑制人类肿瘤异种移植和同源小鼠肿瘤的生长及存活方面表现出显著效果，同时对线粒体毒性较小，且比auranofin具有更好的耐受性。
In vivoTRi-1在小鼠肿瘤模型中的抗癌效力，与TXNRD1对于体内癌细胞生长的重要性这一观点相一致。
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 62.5 mg/mL (190.13 mM)
Keywordsantitumor | inhibit | TRi 1 | Inhibitor | TRi-1 | FaDu | thioredoxin reductase 1 | glutathione | TRi1 | TXNRD1
Related Compound LibrariesInhibitor Library | Bioactive Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Mitochondria-Targeted Compound Library | NO PAINS Compound Library | Covalent Inhibitor Library
TRi-1|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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