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  • 6-羟基黄酮|T2940|TargetMol

6-羟基黄酮|T2940|TargetMol

6-Hydroxyflavone
6665-83-4
￥466 500mg 起订
￥198 100mg 起订
上海 更新日期：2024-12-12

TargetMol中国（陶术生物）

VIP3年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
6-羟基黄酮
英文名称：
6-Hydroxyflavone
CAS号：
6665-83-4
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
99.83%
产品类别：
抑制剂
货号：
T2940

Product Introduction

Bioactivity

名称6-Hydroxyflavone
描述6-Hydroxyflavone (6-HF) is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It is reported in leaves of Barleria prionitis Linn. (a common Acanthaceae from India). 6-Hydroxyflavone may have a potential as a therapeutic drug capable for the treatment of anxiety-like disorders.
激酶实验For Jak3 kinase assays, Fsk-treated MT-2 cells are lysed, clarified, and immunoprecipitated using Jak3 antibody. Kinase reactions are carried out at 30°C for 20 min. For PKA kinase assays, untreated MT-2 cells are lysed, and Jak3 is immunoprecipitated and bound to PAS beads. Immunoprecipitated Jak3 is washed with kinase buffer (50 mM Hepes-NaOH (pH 7.4), 10 mM MgCl2, 0.5 mM EGTA, 0.5 mM DTT, 20 μg/mL aprotinin, 10 μg/mL leupeptin, 1 μg/mL pepstatin A) and incubated with 200 μM ATP and purified protein kinase A catalytic subunit (PKAc) as indicated in the figure legends. Kinase reactions are carried out at 32 °C for 30 min followed by vigorous washing of the beads with cold kinase wash buffer. For [γ-32P]ATP radiolabeled kinase assays using recombinant Jak3, Hek293 cells are transfected with wild type (WT) Jak3 or kinase-dead Jak3 K855A using Lipofectamine 2000 according to the manufacturer's instructions. Cells are lysed and immunoprecipitated with Jak3 antibody. Jak3-bound PAS beads are washed three times in cold lysis buffer followed by kinase buffer. Kinase reactions are initiated by adding 10 μCi [γ-32P]ATP, 10 μM unlabeled ATP, and 1 μg of purified PKAc to Jak3-bound PAS bead reaction mixtures. Kinase reactions are performed at 32°C for 30 min. Jak3-bound PAS beads are washed three times in radioimmunoassay buffer (10 mM Tris-HCl, pH 7.4, 75 mM NaCl, 20 mM EDTA, 10 mM EGTA, 20 mM Na4P2O7, 50 mM NaF, 20 mM 2-glycerolphosphate, 1 mM p-nitrophenylphosphate, 0.1% Triton X-100) and one time in kinase wash buffer. The reactions are stopped by adding 2× SDS-PAGE sample buffer followed by SDS-PAGE. Coomassie stainable Jak3 bands are excised from the PVDF membrane and subjected to phosphoamino acid analysis[2].
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 6.5 mg/mL (27.28 mM), Sonication is recommended.
关键字inhibit | Inhibitor | 6 Hydroxyflavone | 6Hydroxyflavone | 6-Hydroxyflavone
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6-羟基黄酮|||6-HF|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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